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DOPAMINE

                                                    DOPAMINE

  • It is naturally occuring orgainc amine.

Action :-

  • It acts on alpha & beta adrenergic receptors. it additionally acts on dopaminergic  (D2) receptors in renal & mesentric blood vessels, dilates them.
  • ON HEART : it has positive inotropic but little chronotropic effect.
  • Iv infusion raises cardiac output & systolic BP, little effect on diastolic BP.

INDICATIONS :

  • Hemodynamic imbalances present in shock syndrome caused by hypovolaemia,
  • myocardial infarction,
  • trauma.
  • endotoxins
  • septicaemia
  • open heart surgery.
  • acute renal failure & chronic cardiac decompensation in congestive failure.
DOSAGE :-
  • ADULTS : 2-50 mcg.kg.min  can be increased upto 100 mcg/kg/min by slow iv infusion.
  • CHILDREN : 2-20 mcg/kg/min.
CONTRA INDICATION :-
  • pheochromocytoma
  • uncorrected tachycardia
  • ventricular fibrilation
  • hyperthyroidisom
SPECIAL PRECAUTIONS :
  • Dopamine must be diluted before iv administraion. 
  • hypovolamemia must be corrected before administrering.

SIDE EFFECTS :
  • Nausea
  • vomiting
  • ectopic beats
  • tachycardia
  • anginal pain
  • palpations
  • hypotension
  • dyspnoea
  • headache
  • vasoconstriction
DRUG INTERACTIONS :
  • Anaesthetics may cause cardiac arrhythmias,
  • MAOIs increases the effect of dopamin.
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