Rbc Life Cycle
- Rbc live only about 120 days because of the war and tear their plasma membrane undergo as they squeeze through blood capillaries.
- Without nucleus and organells. Rbc can not synthesize the new components to replace and damaged onces.
- The plasma membrane becomes more fragile with age and cells are more likely to brust. Especially as they squeeze they squeeze through narrow channels in the spleen.
- Ruptured red blood cells are removed from circulation and destroyed by fixed phagocytic macro phages in the spleen and liver.
Measurements :
Measurements of red cell numbers volume
and hemoglobin content are usefull assessments made in clinical practice.
Measure
Normal Values
Complete Blood
Count
RBC
Male : 4.5 – 6.5 million/mm.
Female : 3.8 – 5.8 million/mm.
Female : 3.8 – 5.8 million/mm.
HB Infant 14 – 20 g/100ml.
Male : 13.5 – 18 g/100ml.
Female : 12-16 g/ 100ml.
Male : 13.5 – 18 g/100ml.
Female : 12-16 g/ 100ml.
Packed Cell Volume (
PCV,
haematocrit ). The volume of red 0.40 – 0.
cell in 1or mm3 of blood.
haematocrit ). The volume of red 0.40 – 0.
cell in 1or mm3 of blood.
Mean cell volume ( MCV
)
The volume of an average 80 -96 fl.
cell. Measured in femtoliters
( 1 fl = 10-15 liter ).
The volume of an average 80 -96 fl.
cell. Measured in femtoliters
( 1 fl = 10-15 liter ).
Mean Cell Hemoglobin
(MCH)
The average amount of Hb per 27 – 32 pg/cell.
cell measured in pictograms.
( 1pg : 10-12 gram )
The average amount of Hb per 27 – 32 pg/cell.
cell measured in pictograms.
( 1pg : 10-12 gram )
Mean Cell Hemoglobin
Concentration ( MCHC ).
The Weight of Hb in 100ml 30 -35 g/ 100 ml of rbc.
of red cells.
Concentration ( MCHC ).
The Weight of Hb in 100ml 30 -35 g/ 100 ml of rbc.
of red cells.
