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FRUSEMIDE (LASIX)

FRUSEMIDE 

CLASSIFICATION   :    DIURETICS
TRADE NAME          :    LASIX 
GENERIC NAME      :    FRUSEMIDE
  • It is a strong diuretic but lacks specific anti-hypertensive action. ( has no direct effect on resistance vessels). 
  • Thus anti hypertensive efficacy is directly related to diuretic potency. 
  • Fall in BP is due only to reduced plasma extracellular fluid volume.

Indications :

  • Oedema in congestive heart failure,
  • hepatic and renal disease. 
  • Cerebral oedema, 
  • forced diuresis for poisoning, 
  • toxaemia of pregnancy.
  •  Hypertension and hypertensive crisis.
  • Pulmonary edema

  Dosage : 

  •  ADULT : 20-80 mg as a single dose. if satisfactory results are not obtained than 20-40 mg after 6 hrs.  INFANT & CHILDREN : 2mg /kg body wt increased by 1-2 mg/kg 6-8 hrs after the previous dose.  MAX : 40 mg /day.

CONTRA INDICATIONS :

  • Renal failure with anuria,
  • potassium deficiency ( i.e. malnutrition, diarrhoea).
  • Hypersensitivity to frusemide & sulphonamides,
  • Hypokalaemia 
  • Hyponatraemia
  • Hepatic coma
  • Hypovolaemia with/without hypotension.
SPECIAL PRECAUTIONS :
  • Electrolyte imbalance (monitor serum electrolyte)
  • Paediatrics : can be used safely.
  • Pregnancy : Contraindicated.
  • Lactation : Used if clearly indicated.
  • Elderly : Increased risk of side effects. Dose to be reduced.
SIDE EFFECTS :
  • Vertigo.
  • Visual impairment.
  • Sodium deficiency may cause orthostatic hypotension.
  • Calf muscle cramps.
  • Anorexia.
  • Weakness.
  • Dizzinesss.
  • Drowsiness.
  • Vomiting.
  • hyperuricaemia reduced glucose tolerance.
  • Deafness.
DRUG INTERACTIONS :
  •  Aminoglycoside  antibiotics may enhance the risk of deafness, potentiates anti hypertensives, causes litihum toxicity in those receiving both drugs. With cotrimoxazole produces thrombocytopenia. NSAIDs diminish the diuretic effects. 

 

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